We adapt and develop various single-molecule approaches to study the interaction of MMR proteins among themselves and with heteroduplex DNA to elucidate the mechanism of MMR initiation.
- Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair DNA Repair, 2015.
- MutS tetramerization captured by AFM The EMBO J., 2011.
- UVA generates pyrimidine dimers in DNA directly Biophys J. , 2009.
- Detection of UV damage in single DNA molecules Biophys. J., 2007